TP53 and breast cancer: However, the demonstration of the activity of sirtuin inhibitors such as Sirtinol, which induces apoptosis and autophagic cell death in MCF-7 human breast cancer cells [25], or Salermide, which targets both Sirt1 and Sirt2 and, in so doing, induces cell death and p53 acetylation, again in MCF-7 cells [26], shows the potential of sirtuin inhibitors in cancer therapy.