The antiviral-ISG, including GBP1, IFI44, IFIH1, IFIT1, MX1, and LY6E, were the most common group of up-regulated genes after influenza infection [69], yellow fever vaccination [70], and during febrile episodes of dengue hemorrhagic fever [71], [72]. This evidence concerns the gene LY6E and Dengue hemorrhagic fever.