IGHE and systemic lupus erythematosus: We then measured the serum IgE levels and we observed a significant increase of IgE concentrations in SLE patients (n=23, 17 patients with a SLEDAI score<5 and 6 patients with a SLEDAI score>8) compared to sera from healthy individuals (n=23; 233±57 pg/ml), and this increase was more pronounced in patients with an active disease (917±355 pg/ml in patients with active SLE, p<0.01 and 633±106 pg/ml in patients with inactive SLE, p<0.05; Figure 6B).