ProBNP1-108 was initially considered to be cleaved inside the cardiomyocytes into NT-proBNP (the biologically inactive NH2-terminal peptide fragment proBNP1-76) and the BNP (the biologically active hormone) [1,2]; both are more and more useful for clinical application [1,3,4], including diagnosis [3], treatment [3], prognosis [3], follow-up of patients with cardiac involvement, mainly heart failure (HF). This evidence concerns the gene NPPB and heart failure.