BMPs have also been implicated in the formation of new bone induced by prostate cancer and the inhibition of BMPs by their inhibitor Noggin in C4-2B cells induces a decrease in the osteoblastic response, suggesting that the low expression level of Noggin in PC3c cells compared with PC3 cells may also contribute to the osteoblastic lesions induced by PC3c cells [4,10]. Here, NOG is linked to prostate cancer.