We showed that sWRE can inhibit human breast cancer cell invasion in vitro and metastasis in both allograft and xenograft breast cancer mouse models, similar to the pure small molecule Withaferin A. sWRE induces vimentin reorganization and morphologic cellular changes in human breast cancer cells and, importantly, inhibits EMT induction in normal human mammary epithelial cells. Here, VIM is linked to breast carcinoma.