VIM and metastatic neoplasm: Numerous reports show that vimentin is a classic EMT biomarker that is expressed in aggressive cell lines and tumors [46-53], and correlates with high grade cancer and metastatic disease [54-58]; Nevertheless, the precise molecular role of vimentin in cell motility remains largely undefined and there are several reports that induced vimentin expression in vimentin null cell lines does not impact motility [59,60].