Besides, many studies have reported that gene polymorphisms, including cytokine or chemokine genes (e.g., IL-1β, TNF-α, IL-10 and IL-8) and the innate immune response genes (e.g., Toll-like receptor and mannose-binding lectin2) responded to H. pylori infection, are associated with GC susceptibility [27–30]. The gene discussed is IL1B; the disease is gastric cancer.