Unlike IGFBP3, which induces antitumor activity in different types of cancers [8,9], IGFBP2 has been shown to promote tumorigenesis [10], cancer cell invasion [11], metastasis [12], cancer stem cell expansion [13], and tumor angiogenesis [12,14] in various types of cancers. Here, IGFBP2 is linked to neoplasm.