Our results showed that blood IGFBP2 levels were significantly higher in lung cancer patients than in healthy controls, which are consistent with a recent study on serum IGFBP2 levels in 98 lung cancer patients, 17 benign lung disease and 23 normal controls in China, in which serum IGFBP2 levels and its autoantibodies were significantly elevated in lung cancer patients [33]. Here, IGFBP2 is linked to lung cancer.