IGFBP2 and neoplasm: Immunohistochemical analysis showed that the IGFBP2 expression was not detectable in the primary tumor of a patient with low blood IGFBP2 level but was markedly elevated in the tumor of a patient with high blood IGFBP2 (Figure 2B), suggesting that blood IGFBP2 levels may reflect IGFBP2 expression in the tumors.