The fact that haplotype analysis did not reveal an association more significant than that of individual SNPs, and that our previous resequencing of the H2AFX gene and upstream region in 95 NHL cases found no evidence for frequent rare mutations [10] make this explanation unlikely, unless the undetected SNP is either downstream or more than 1 Kb upstream of H2AFX. The lower LD between SNPs in this region in different ethnic populations may assist in determining which variant is responsible. This evidence concerns the gene H2AX and non-Hodgkin lymphoma.