VEZT suppressed the proliferation, migration, invasion and tumorigenesis of gastric cancer cells, which involved the cell migration and invasion genes (CDC42,GPR56,HMGN5, MXD1 and DSTN) and growth genes (CDIPT,FOXP1, GPR56), as well as inducing cellular adhesion genes (PLCD1, ITGA5 and HOXD3) and a cell cycle progression gene (TCF19). This evidence concerns the gene HMGN5 and gastric cancer.