This information could be of crucial importance for the co-evolution between EBHSV and hares MHC genes, considering that “central European” and “Greek” strains of the virus were found to be phylogenetically divergent [23], which was reconfirmed in our current study (average genetic distance 0.082 Danish vs other European and 0.075 Danish vs Greek).We hope that an ongoing study on the prevalence of infectious diseases, especially of EBHSV, among brown hares in Greece in association with the distribution of class II MHC alleles will shed more light on this issue. This evidence concerns the gene HLA-C and infectious disease.