In the present study, we recruited 402 patients with paranoid schizophrenia and 406 control subjects to examine the putative association between paranoid schizophrenia and polymorphisms in BDNF (rs6265) and NTRK2 genes (rs1387923, rs2769605, and rs1565445) in a Chinese Han population. This evidence concerns the gene NTRK2 and schizophrenia.