The lack of association between PNPLA3 GG genotype and atherosclerosis in older patients, together with the selection of a population at high cardiovascular risk (i.e. NAFLD/NASH), could explain why the I148M PNPLA3 gene variant was not identified as a risk factor for cardiovascular diseases/events in GWAS studies, [30], [31] other than a recent report observing a link between ICAM-1 serum levels and PNPLA3 genotype in a large cohort of healthy women. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatohepatitis.