[15], [16] Because NAFLD is the liver expression of a systemic metabolic dysregulation, we hypothesized that SNPs of genes associated with NAFLD and its severity -PNPLA3, GWAS-derived genes like neurocan (NCAN), glucokinase regulatory protein (GCKR), lysophospholipase-like 1 (LYPLAL1) [17], and IL28B which have been recently associated with hepatic lobular inflammation and fibrosis [18] - could also be linked to the severity of systemic, and in particular cardiovascular alterations in this setting of patients. The gene discussed is PNPLA3; the disease is metabolic dysfunction-associated steatotic liver disease.