PNPLA3 and liver disorder: A possible hypothesis would be that in younger patients, where the role of aging and classic atherosclerosis risk factors are weaker, PNPLA3 can fully exert its atherogenic role; in older patients, as effect of PNPLA3-induced liver disease progression, the reduction of LDL levels (115.1±38.6 mg/dl in F3–F4 vs. 128.9±38.2 mg/dl in F0–F2 Sicilian cohort) [29] and arterial pressure values associated with advanced liver disease might counterbalance the potential atherogenic role of the PNPLA3 genotype, vanishing the differences in IMT of the different polymorphisms.