Interestingly, in the validation cohort of Northern Italian NAFLD patients, vascular alterations were also not different according to PNPLA3 genotype in the total population, but in patients younger than 50 a link between atherosclerosis and PNPLA3 GG genotype was again observed, and maintained after correction for well known risk factors. The gene discussed is PNPLA3; the disease is atherosclerosis.