CCR4 and hyperinsulinemic hypoglycemia, familial, 4: Indeed, while other studies reported a role for CCR4, whose ligands are altered by Aire deficiency [15], in the formation of a normal DETC in the epidermis of adult mice [19], the role of CCR4 during intrathymic Vγ5+ DETC progenitor migration and development, culminating in the initial seeding of the epidermis in the neonate, has not been fully studied.