APC and neoplasm: Notably, the Apc- and Apc/KRAS-mutant genotypes are not resolved by HCA and PCA, possibly due to the relatively limited number of Apc1638N/+ and Apc1638N/+/KRASV12G tumour samples (n = 5 for each group) employed for the comparative expression profiling analysis, insufficient to highlight the allegedly more subtle differences between benign and malignant CSCs.