APC and neoplasm: Overall, these results show that CSCs from Apc- and Apc/KRAS-mutant tumours have distinct expression profiles from other tumour cell populations and are characterized by increased Wnt signalling activity, in agreement with their enhanced levels of intracellular β-catenin, together with other signalling pathays (Bmp, Igf), and by the expression of Paneth cell-specific genes.