STAT3 and cancer: In addition, other cancer-related TFs, such as AP1, STAT3, EGR1, CEBPB and SP1, have been experimentally and individually studied in HNSCC and other cancers [15], [22], [23], [24], [25], [26], and implicated in complex cross-talk with p53 or NF-κB pathways [22], [26], [27], [28], [29], [30].