We have shown that some p53 genes in the networks are also known to be regulated by p63, such as CDKN1A, IGFBP3, PERP, S100A2, SERPINB5, and SFN. Another example gene JAG1 is a known binding target of mir21, mir34a and p63, supporting the potential of p63 interacting with TFs and miRNAs in gene regulation of HNSCC. The gene discussed is S100A2; the disease is head and neck squamous cell carcinoma.