Apart from IL8, the co-regulation between NF-κB and AP1, CEBPB or STAT3 for genes IL1B, ICAM1, IL6, PTGS2, and SAA1 in the TF regulatory networks (Figure 2B) is consistent with previous observation in HNSCC or other cancer cells [49], [50], [51], [52], [53], [54]. The gene discussed is IL6; the disease is head and neck squamous cell carcinoma.