These genes mediate immune and inflammatory responses (CSF2, IL1A, IL1B, IL1RN, IL1R2, IL6, and IL8), apoptosis (CDKN1A and IGFBP3), and adhesion (ITGA5, LAMA3, LAMB3 and ICAM1), validated in HNSCC cell lines (Figure 5, and [16]). This evidence concerns the gene CXCL8 and head and neck squamous cell carcinoma.