These genes mediate immune and inflammatory responses (CSF2, IL1A, IL1B, IL1RN, IL1R2, IL6, and IL8), apoptosis (CDKN1A and IGFBP3), and adhesion (ITGA5, LAMA3, LAMB3 and ICAM1), validated in HNSCC cell lines (Figure 5, and [16]). The gene discussed is IL1RN; the disease is head and neck squamous cell carcinoma.