Several common target genes in the networks were down-regulated in both wt and mt tumor cells (Figure 3, Table S4), such as ITGA5 and S100A2 (adhesion and migration), SERPINE1 (angiogenesis), CDKN1A (growth arrest), and PLAU and SERPINE5 (proteolysis). This evidence concerns the gene CDKN1A and neoplasm.