A vaccination study addressing oral administration of inactivated cholera vaccine in young children in a cholera endemic country revealed an enhancing effect of zinc supplementation every day for 42 days (starting 3 weeks prior to vaccination) on the Th1 response, IFN-γ secretion and the vibriocidal antibody response, particularly in formerly zinc-deficient children [42]. This evidence concerns the gene IFNG and vibrio infectious disease.