In this study, the predictive value of HMW-adiponectin for metabolic syndrome by ROC analysis was not significantly greater than that of BMI or waist circumference and adding HMW-adiponectin to BMI or waist circumference did not improve predictive ability, suggesting the lack of utility of HMW-adiponectin to predict future development of metabolic syndrome. Here, ADIPOQ is linked to metabolic syndrome.