TIAM1 and colorectal carcinoma: In order to better understand the role and mechanism of Tiam1 in progression of CRC, we generated pCDFl-Tiaml-copGFP transgenic mice and investigated the influence of Tiaml on the development of carcinomas in the colon and rectum that were induced by the chemical carcinogen (DMH), in combined with histological observation of local invasion and distant metastasis.