Some studies demonstrated that upregulation of Tiam1 is correlated to aggressive behavior of human cancer and poor clinical outcome of patients in several types of malignant tumors, such as breast cancer, colon cancer, prostate cancer, liver cancer, nasopharyngeal carcinoma, as well as esophageal squamous cell carcinoma (ESCC) [4], [5], [6], [7], [8], [9]. The gene discussed is TIAM1; the disease is breast carcinoma.