Prior research reported that polymorphic variations in exon (rs5498 and rs5491) or intron (rs281432) regions of the ICAM-1 gene and in the region (rs3093030) between the ICAM-1 and ICAM-4 genes were associated with risks for prostate cancer, gastric cancer, breast cancer, type 1 diabetes, metabolic syndrome, and systemic lupus erythematosus [28]–[33]. This evidence concerns the gene ICAM1 and Familial prostate cancer.