Alleles with the highest distribution frequency for the rs3093030, rs5491, rs281432, and rs5498 genes of ICAM-1 in both of our recruited oral-cancer patients and healthy controls were respectively homozygous for C/C, homozygous for A/A, homozygous for C/C, and homozygous for A/A. This evidence concerns the gene ICAM1 and lip and oral cavity carcinoma.