ICAM1 and neoplasm: Binding of tumor cells to endothelial ICAM-1 [18] leads to auto-upregulation of tumor ICAM-1 and more importantly to chemotaxis of tumor-associated macrophages and neutrophils that eventually facilitate loosening of adhesive contacts and the breaking down of endovascular barriers, permitting tumor cell migration, neoangiogenesis, and ultimately instability of the tumor environment [15]–[17].