Moreover, people who were either polymorphic for ICAM-1 in 4 loci (rs3093030, rs5491, rs281432, and rs5498) or who smoked were at a 4.17∼8.06-fold risk (p<0.05) of developing oral cancer, compared to people with the WT gene who did not smoke (Table 5). Here, ICAM1 is linked to lip and oral cavity carcinoma.