HGF and cancer: For instance the MAPK pathway, which is frequently hyperactivated in tumors, can promote the acquisition of an invasive and migratory phenotype by modulating the AS pattern of the cell adhesion molecule CD44. In fact, it has been shown that hepatocyte growth factor (HGF) can induce cell migration of cancer cells by promoting this splicing event, as a consequence of induced ERK1/2-mediated phosphorylation of SAM68, induced by the MET receptor signaling pathway [110].