Some of these phosphatases are implicated in human diseases, for instance OCRL1 mutations are associated with Lowe’s syndrome and Dent 2 disease (95, 97), SKIP and 72-5ptase/Type IV/Inpp5e are implicated in insulin signaling and glucose homeostasis while Synaptogenin1 in mice is required for neuronal function. This evidence concerns the gene OCRL and oculocerebrorenal syndrome.