ICN-target genes such as Myc[60], [61], [62], Hes1[47], [63], Notch3[64], [65] and IGF1R[66] are critical to T cell development and T-ALL, and Notch signaling directly controls expression of T-cell-lineage specific identity genes such as Tcf7[67], [68] and Bcl11b[69]. This evidence concerns the gene HES1 and acute lymphoblastic leukemia.