Interestingly, several proteins specifically induced (c-Jun, MAPK1/ERK2, MAPK3/ERK1, and others) or lost (AKT1, PCNA, Smad2, and others) from the infected phosphoproteome have high BC values indicated by relatively large node size (Figs. 4 and 5). The gene discussed is AKT1; the disease is breast cancer.