Even after excluding the two essential kinases (PLK1 and AURKB), the 18 TIMMA-selected kinases showed higher cancer cell growth inhibition power in the single knock-down experiments (22% increase in cell inhibition), compared to the inhibition observed in the kinome-wide single-siRNA screen (Wilcoxon rank sum test, p = 0.28, Supplementary Table S2). The gene discussed is PLK1; the disease is cancer.