For example, the PRDM16 gene in 1p36, which codes for a transcription factor, and the RPN1 gene in 3q21, which codes for type I integral membrane protein found in the rough endoplasmic reticulum, are rearranged in AML with t(1;3)(p36;q21) (28). The gene discussed is RPN1; the disease is acute myeloid leukemia.