While our recent studies demonstrated the expression of FGF21 in the liver in response to experimental myocardial ischemia and the cardioprotective role of FGF21 during the acute phase of myocardial injury (24 hrs)24, the present investigation demonstrated FGF21 upregulation in not only the liver, but also the adipose tissue. This evidence concerns the gene FGF21 and myocardial ischemia.