HF/HS feeding increased the expression of hepatic 3-hydroxy-3methyl-glutaryl-CoA reductase (HMGCR) and 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS), whereas Yabukita 1% and Benifuuki 1% diets lowered their expressions to those seen in controls. This evidence concerns the gene HMGCR and hydrops fetalis.