Ang II plays an essential role in myocardial fibrosis by enhancing activation of transforming growth factor-β (TGFβ) and connective tissue growth factor (CTGF), which may further facilitate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling[1,5,6]. This evidence concerns the gene MAPK3 and Myocardial fibrosis.