CFH and age-related macular degeneration: The Y402H polymorphism (rs1061170) in the complement factor H (CFH) gene [19-21], and the A69S polymorphism (rs10490924) in the Age-Related Maculopathy Susceptibility 2 (LOC387715/ARMS2) [22,23] have been shown to be the strongest genetic factors to confer AMD susceptibility.