To our knowledge there has not been a reported study regarding peroxiredoxin-4 protein expression in human gastric cancer adenocarcinoma AGS cells response to vitamin C. Therefore, a detailed study is necessary regarding the effects of vitamin C on peroxiredoxin-4 protein expressions and the role of peroxiredoxin-4 protein in tumorigenesis of gastric cancer. This evidence concerns the gene PRDX4 and gastric cancer.