SLC11A1 and microcytic anemia: In mammals, Nramp1 (Slc11A1) expression is restricted to macrophages, but a second Nramp protein, (Nramp2, Slc11A2, or DMT1), is localized in the plasma membrane of several tissues, and mutations have been linked to severe microcytic anemia and serum and hepatic overload (Courville et al., 2006; Shawki et al., 2012).