CSF1R and Hodgkins lymphoma: Hypomethylation often affects HERV-derived solo LTRs that function as alternate promoters, for example the HERV-derived LTR is hypomethylated in B cell-derived Hodgkin’s lymphoma and is responsible for deregulated expression of the colony-stimulating factor 1 receptor (CSF1R), a protooncogene (13).