Indeed, in the kidney CD73 participates in the production of adenosine that mediates tubuloglomerular feedback (Castrop et al. 2004), provides renoprotective adenosine that renders the kidneys more tolerate to acute ischemia/reperfusion (Grenz et al. 2007), and produces adenosine in response to chronic exposure to angiotensin II leading to A2B receptor-induced chronic renal disease and hypertension (Zhang et al. 2013). Here, NT5E is linked to chronic kidney disease.