MC4R and obesity disorder: rs17782313, a single nucleotide polymorphism (SNP), mapping to a locus 188kb downstream of MC4R, is speculated to participate in the function and/or expression of MC4R and the minor allele (C, minor allele frequency about 27% in white Europeans) is associated with a higher prevalence of common human obesity in genome-wide association studies (GWAS) [1], [6]–[9], with increased occurrence of snacking behavior [10], and a higher hunger score on the Three-Factor Eating Questionnaire (TFEQ [11]).