MC4R and obesity due to melanocortin 4 receptor deficiency: A recent meta-analyses on the association between common polymorphisms near the MC4R gene and obesity risk confirmed an association between rs17782313 and obesity under the assumption of each, additive, dominant, recessive and allelic models, with the highest odds ratio (OR) observed for a recessive model: OR of additive model 1.18, dominant model 1.26, recessive model 1.41 and allelic model 1.24 [29], and thereby providing supporting evidence for the plausibility of assuming a recessive mode of inheritance for this SNP in the current study.