EGR1 and early-onset autosomal dominant Alzheimer disease: Moreover, EGR-1 is up regulated in brain of patients with Alzheimer disease (AD), and overexpression of EGR-1 controls both phosphorylation and dephosphorylation of tau, by activating CDK5 and inactivating PP1, leading to tau hyperphosphorylation and destabilized microtubules [14].