SIN could also reduce the invasion and migration in co-cultured fibroblast-like synoviocytes and human THP-1 cells by inhibiting MMP-2, MMP-9 and CD147 expression [22], suppress the IL-1β-induced genes expression in a human synovial sarcoma cell line [23], as well as protect IL-1β-induced proteoglycan degradation and apoptosis in rabbit articular cartilage and chondrocyte [24]. The gene discussed is IL1B; the disease is synovial sarcoma.