We show that BMP7 markedly stimulates BAT volume and activity in mice only at subthermoneutral temperature, accompanied by a reduction in diet-induced obesity, liver lipid accumulation, dyslipidemia and hyperglycemia, and an altering of the M1/M2 balance in BAT and WAT towards increased anti-inflammatory M2 macrophages. Here, BMP7 is linked to Hyperglycemia.