BMP7 and obesity due to melanocortin 4 receptor deficiency: To investigate if BMP7 could improve the metabolic phenotype in diet-induced obesity, C57Bl6/J mice were fed a high-fat diet for 12 weeks and then treated with BMP7 (100 μg/kg/day) or saline for four weeks via subcutaneous osmotic minipumps in the presence of a high-fat diet.