IGF2 and neoplasm: For instance, microsatellite markers revealed common inactivating mutations or loss of heterozygosity (LOH) at 17p13, a region that includes the TP53 tumor suppressor gene, LOH at 11q13 (MEN1 locus), and alterations of the imprinted 11p15 locus (paternal isodisomy) leading to IGF2 overexpression [16,17].