Finally, a recent paper showed that a mouse model with a combination of stabilized β-catenin and elevated IGF2 expression presented larger adrenal glands, displayed earlier onset of hyperplasia, and developed more frequent macroscopic adenomas (as well as one carcinoma) than the models with only one alteration, suggesting the need of an accumulation of a second or multiple alterations for tumorigenesis [10]. This evidence concerns the gene IGF2 and adenoma.