IGF2 and adrenal cortex carcinoma: On the other hand, IGF2 expression was significantly increased in ACC (P<0.001), especially in those samples affected by cnLOH or LOH associated with CN losses (Figure 7A), thus suggesting a possible multistep genomic aberration at this locus (i.e. first a duplication of the paternal allele followed by the loss of the maternal allele and as late step by the loss also of one paternal allele).