TNF and colitis: However, in comparison with the mice with TNBS-induced colitis, the mRNA levels of c-Maf, TNF-α and IFN-γ were significantly reduced by 56% (p = 0.018), 49% (p = 0.028) and 58% (p = 0.012), respectively, in mice administered 100 mg/kg sinomenine, and the levels were decreased by 80% (p = 0.002), 55% (p = 0.014) and 71% (p = 0.004), respectively, with 200 mg/kg sinomenine (Figures 3B, C, D).