RPE65 and Leber congenital amaurosis: LCA is caused by mutations in 23 genes meanwhile; the major contributing one includes GUCY2D, CRB1, RPE65, CEP290, RPGRIP1, RDH12, AIPL1, CRX, LCA5, TULP1, LRAT, IMPDH1, RD3, MERTK, SPATA7[6].