Importantly, CD4+ T cells were required for the generation of therapeutic primary immune responses for both tumor models, but the requirement for CD4+ T cell help for the generation/maintenance of long-term immune memory was dependent on the nature of TAA, SVN as self TAA required CD4+ T cells, whereas HPV E7 as xenogeneic viral TAA bypassed such a requirement. The gene discussed is CD4; the disease is neoplasm.