Given the critical role of CD8+ T cells in recall responses against tumor and control of recurrences and the demonstrated role of CD4+ T cells in the generation/maintenance of CD8+ T cell memory responses under selected settings, we assessed the effect of CD4+ T cells depletion during the primary responses on long-term immune memory against TC-1 expressing xenogeneic viral E7 TAA vs. 3LL expressing autologous self-antigen SVN. This evidence concerns the gene CD8A and neoplasm.