TNFRSF11A and pachyonychia congenita: In this communication, we used a multiplexed quantum-dot labeling based quantitative histopathology approach at a single cell level as reported previously by our group [6] to assess the expression of cell signaling pathway components downstream from a RANK- and c-Met-mediated signaling network in clinical PC specimens collected from interracial groups, comprised of Caucasian-Americans, African-Americans and Chinese patients, and assessed if these signaling pathway components can predict the survival of PC patients.