POPDC1 and Tetralogy of Fallot: Hypermethylation of the Popdc1 promoter was observed during tumorigenesis and was correlated with the downregulation of Popdc1 expression [15]–[17] and mutated Popdc1 has been identified in patients born with Fallot's tetralogy [18], suggesting a potential role for Popdc1 in the control of cell growth and differentiation and in heart morphogenesis.