CXCL8 and chronic kidney disease: On the other hand, based on the available data, we consider that the proinflammatory cytokines (IL-6 and TNF-α), the chemokine, CXCL8/IL-8, and the fibrogenic cytokine, TGF-β, should be more intensively evaluated as potential biomarkers for renal scarring and for the emergence of CKD in reflux nephropathy (Table 2).