Also the tumor suppressor gene p53 can regulate Th17 functions by inhibiting production of IL-17 in patients with RA and participate in the pathogenesis of RA [20], and the downstream of p53 transcriptional target gene Bax involved in the effect of sulforaphane (SFN) inhibit the production of IL-17 by rheumatoid T cells in vitro [36]. This evidence concerns the gene BAX and rheumatoid arthritis.