CNTNAP2 and Isaacs syndrome: Whereas antibodies directed against channel-associated proteins have been shown to immuno-precipitate the solubilized channel in radioimmune assays, in neuromyotonia and also in (limbic) encephalitis, the autoantibody has been shown in diagnostic cell-based assays to be directed not against the potassium channel alpha subunit, but against leucine-rich glioma inactivated 1 (Lgi1) or contactin-associated protein-like 2 (Caspr2) which both are channel-associated proteins (Lai et al., 2010; Dalmau et al., 2011).