ADIPOQ and diabetes mellitus: Because HMW adiponectin is best associated with diabetes and metabolic syndrome (18, 19) and because glycosylation of lysine is an important modification that drives intracellular AMP-kinase signaling, a new method is presented to provide a differential measurement of tryptic adiponectin peptides that could reflect some degree of lysine modification to serve as a proxy of adiponectin modification and possibly multimerization.