Indeed, a recent study examined the effect of icv H3 relaxin on anxiety-like behavior in rats and observed an anxiolytic effect in the elevated plus maze test and the shock probe-burying test (70), consistent with our studies demonstrating that icv administration of a selective RXFP3 agonist peptide reduced anxiety-like behavior in the light-dark box and elevated plus maze (96). This evidence concerns the gene RXFP3 and Anxiety.