Limberg and collaborators have identified two novel heterozygous KCNJ2 mutations (p.N318S, p.W322C) located in the C-terminus of the Kir2.1 potassium channel subunit in a large set of patients with congenital long-QT syndrome (Limberg et al., 2013). This evidence concerns the gene KCNJ2 and Prolonged QT interval.