Thus, as it has been shown that glycosylation could differ according to the location within the heart tissue (Montpetit et al., 2009) and as electrical remodeling in cardiac disease is usually ascribed to altered expression and distribution of ion channel proteins such as Nav1.5, the location of any mutation in these consensus sites of modification should be considered as probable causes of arrhythmia occurrence. Here, SCN5A is linked to cardiac arrhythmia.